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fc alk5  (R&D Systems)


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    Structured Review

    R&D Systems fc alk5
    Fc Alk5, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fc alk5/product/R&D Systems
    Average 92 stars, based on 3 article reviews
    fc alk5 - by Bioz Stars, 2026-03
    92/100 stars

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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and <t>IgG</t> were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.
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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and <t>IgG</t> were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.
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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and <t>IgG</t> were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.
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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and <t>IgG</t> were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.
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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and <t>IgG</t> were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.
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    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and IgG were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.

    Journal: Scientific Reports

    Article Title: Interleukin 37 promotes angiogenesis through TGF-β signaling

    doi: 10.1038/s41598-017-06124-z

    Figure Lengend Snippet: TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and IgG were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.

    Article Snippet: Recombinant soluble chimeric protein containing the ectodomain of human ALK1 conjugated with IgG Fc (ALK1-Fc), chimeric protein containing the ectodomain of human ALK5 conjugated with IgG Fc (ALK5-Fc) and chimeric protein containing ectodomain of human TβRII conjugated with IgG Fc (TβRII-Fc) were purchased from Sinobiological (Beijing, China).

    Techniques: Binding Assay, Incubation, Flow Cytometry, Fluorescence, Transfection, Recombinant